• Brucella pinnipedialis in hooded seal (Cystophora cristata) primary epithelial cells 

      Larsen, Anett Kristin; Godfroid, Jacques; Nymo, Ingebjørg Helena (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-01-25)
      Background: Marine Brucella spp. have been isolated from numerous pinniped and cetacean species, but pathological findings in association with infection with Brucella pinnipedialis in pinnipeds have been sparse. The capacity of brucellae to survive and replicate within host macrophages underlies their important ability to produce chronic infections, but previous work has shown that B. pinnipedialis ...
    • Cervid herpesvirus 2 and not Moraxella bovoculi caused keratoconjunctivitis in experimentally inoculated semi-domesticated Eurasian tundra reindeer 

      Tryland, Morten; Sanchez Romano, Javier; Marcin, Nina; Nymo, Ingebjørg Helena; Josefsen, Terje Domaas; Sørensen, Karen Kristine; Mørk, Torill (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-24)
      Background: Infectious keratoconjunctivitis (IKC) is a transmissible disease in semi-domesticated Eurasian reindeer (Rangifer tarandus tarandus). It is regarded as multifactorial and a single causative pathogen has not yet been identified. From clinical outbreaks we have previously identified Cervid herpesvirus 2 (CvHV2) and Moraxella bovoculi as candidates for experimental investigations. Eighteen ...
    • Concomitant Temperature Stress and Immune Activation may Increase Mortality Despite Efficient Clearance of an Intracellular Bacterial Infection in Atlantic Cod 

      Larsen, Anett Kristin; Nymo, Ingebjørg Helena; Sørensen, Karen Kristine; Seppola, Marit; Rødven, Rolf; Jiménez de Bagüés, María Pilar; Al Dahouk, Sascha; Godfroid, Jacques (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-04)
      The environmental temperature has profound effects on biological systems of marine aquatic organisms and plays a critical role in species distribution and abundance. Particularly during the warmer seasons, variations in habitat temperature may introduce episodes of stressful temperatures which the organisms must adapt to and compensate for to maintain physiological homeostasis. The marine environment ...
    • Entrance and survival of Brucella pinnipedialis hooded seal strain in human macrophages and epithelial cells 

      Larsen, Anett Kristin; Nymo, Ingebjørg Helena; Briquemont, Benjamin; Sørensen, Karen Kristine; Godfroid, Jacques (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Marine mammal Brucella spp. have been isolated from pinnipeds (B. pinnipedialis) and cetaceans (B. ceti) from around the world. Although the zoonotic potential of marine mammal brucellae is largely unknown, reports of human disease exist. There are few studies of the mechanisms of bacterial intracellular invasion and multiplication involving the marine mammal Brucella spp. We examined the infective ...
    • Experimental challenge of atlantic cod (Gadus morhua) with a brucella pinnipedialis strain from hooded seal (Cystophora cristata) 

      Nymo, Ingebjørg Helena; Seppola, Marit; Sascha, Al Dahouk; Bakkemo, Katrine Ryvold Arnesen; Jiménez de Bagüés, María Pilar; Godfroid, Jacques; Larsen, Anett Kristin (Peer reviewed; Journal article; Tidsskriftsartikkel, 2016-07-14)
      Pathology has not been observed in true seals infected with Brucella pinnipedialis. A lack of intracellular survival and multiplication of B. pinnipedialis in hooded seal (Cystophora cristata) macrophages in vitro indicates a lack of chronic infection in hooded seals. Both epidemiology and bacteriological patterns in the hooded seal point to a transient infection of environmental origin, possibly ...
    • Fôring av reinsdyr – og fôringsrelaterte sykdommer 

      Eilertsen, Svein Morten; Winje, Erlend; Davidson, Rebecca K.; Mørk, Torill; Nymo, Ingebjørg Helena (Research report; Forskningsrapport, 2022)
    • Infectious Disease Outbreak Associated with Supplementary Feeding of Semi-Domesticated Reindeer 

      Tryland, Morten; Nymo, Ingebjørg Helena; Sanchez Romano, Javier; Mørk, Torill; Klein, Joern; Rockström, Ulrika (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-18)
      Supplementary winter feeding of semi-domesticated reindeer (<i>Rangifer tarandus tarandus</i>) has become more common in Sweden and Norway due to reindeer pasture fragmentation and climatic conditions. With increased corralling and feeding, often associated with animal stress, increased animal-to-animal contact, and poor hygienic conditions, an altered range of health challenges and diseases may ...
    • Infectious keratoconjunctivitis in semi-domesticated Eurasian tundra reindeer (Rangifer tarandus tarandus): Microbiological study of clinically affected and unaffected animals with special reference to cervid herpesvirus 2 

      Sanchez Romano, Javier; Mørk, Torill; Laaksonen, Sauli; Ågren, Erik; Nymo, Ingebjørg Helena; Sunde, Marianne; Tryland, Morten (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-16)
      Background<br> Infectious keratoconjunctivitis (IKC) is one of the most common ocular diseases in ruminants worldwide. In addition to keratitis and conjunctivitis, animals with IKC can develop uveitis, corneal ulcer, and in severe cases, blindness. The bacteria Moraxella spp. has been described as the primary causative agent of infectious bovine keratoconjunctivitis (IBK) in cattle (Bos taurus), ...
    • Infectious keratoconjunctivitis in semi-domesticated reindeer (Rangifer tarandus tarandus): a questionnaire-based study among reindeer herders in Norway and Sweden 

      Wallin Philippot, Karin; Baron, Jerome; Sánchez Romano, Javier; Rautiainen, Heidi; Frössling, Jenny; Nymo, Ingebjørg Helena; Persson, Ylva; Omazic, Anna; Tryland, Morten (Journal article; Tidsskriftartikkel, 2023-07-12)
      Background - The effects of climate change, loss of pastureland to other land usage and presence of large carnivores are the main reasons for the increase in supplementary feeding of semi-domesticated reindeer (Rangifer tarandus tarandus) in Fennoscandia over the last decades. Feeding might expose reindeer to stress and increased animal-to-animal contact, leading to an increased risk of infectious ...
    • Inkoo and Sindbis viruses in blood sucking insects, and a serological study for Inkoo virus in semi-domesticated Eurasian tundra reindeer in Norway 

      Shakya, Ruchika; Tryland, Morten; Vikse, Rose; Romano, Javier Sánchez; Åsbakk, Kjetil; Nymo, Ingebjørg Helena; Mehl, Reidar Arne; Evander, Magnus; Ahlm, Clas; Vapalahti, Olli; Lwande, Olivia Wesula; Putkuri, Niina; Johansen, Wenche; Soleng, Arnulf; Edgar, Kristin Skarsfjord; Andreassen, Åshild Kristine (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-03)
      Background: Mosquito-borne viruses pose a serious threat to humans worldwide. There has been an upsurge in the number of mosquito-borne viruses in Europe, mostly belonging to the families Togaviridae, genus Alphavirus (Sindbis, Chikungunya), Flaviviridae (West Nile, Usutu, Dengue), and Peribunyaviridae, genus Orthobunyavirus, California serogroup (Inkoo, Batai, Tahyna). The principal focus of this ...
    • Marine Mammal Brucella Reference Strains Are Attenuated in a BALB/c Mouse Model 

      Nymo, Ingebjørg Helena; Arias, Maykel; Pardo, Julian; Álvarez, María Pilar; Alcaraz, Ana; Godfroid, Jacques; Jiménez de Bagüés, María Pilar (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-03-09)
      Brucellosis is a zoonosis of worldwide distribution with numerous animal host species. Since the novel isolation of Brucella spp. from marine mammals in 1994 the bacteria have been isolated from various marine mammal hosts. The marine mammal reference strains Brucella pinnipedialis 12890 (harbour seal, Phoca vitulina) and Brucella ceti 12891 (harbour porpoise, Phocoena phocoena) were included in ...
    • A Multi-Pathogen Screening of Captive Reindeer (Rangifer tarandus) in Germany Based on Serological and Molecular Assays 

      Sanchez Romano, Javier; Grund, Lisa; Obiegala, Anna; Nymo, Ingebjørg Helena; Ancin-Murguzur, Francisco Javier; Li, Hong; Król, Nina; Pfeffer, Martin; Tryland, Morten (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-20)
      Captive reindeer in German zoos and wildlife parks live outside their natural geographic range and are exposed to a variety of viral, bacterial and protozoan pathogens, some host-specific and some which they are not exposed to in their native habitat. Reindeer blood samples and ticks collected in 2013 from 123 reindeer at 16 different zoological facilities were available from a previous study. The ...
    • Multi-pathogen serological survey of migratory caribou herds: A snapshot in time 

      Carlsson, Anja M.; Curry, Patricia S.; Elkin, Brett T.; Russell, Donald E.; Veitch, Alasdair M.; Branigan, Marsha; Campbell, Mitch; Croft, Bruno; Cuyler, Christine; Côté, Steeve D.; Leclerc, Lise-Marie; Tryland, Morten; Nymo, Ingebjørg Helena; Kutz, Susan J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-31)
      Pathogens can impact host survival, fecundity, and population dynamics even when no obvious disease is observed. Few baseline data on pathogen prevalence and diversity of caribou are available, which hampers our ability to track changes over time and evaluate impacts on caribou health. Archived blood samples collected from ten migratory caribou herds in Canada and two in Greenland were used to test ...
    • Pathogen Exposure in White Whales (Delphinapterus leucas) in Svalbard, Norway 

      Nymo, Ingebjørg Helena; Siebert, Ursula; Baechlein, Christine; Postel, Alexander; Breines, Eva Marie; Lydersen, Christian; Kovacs, Kit M.; Tryland, Morten (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-29)
      The Svalbard white whale (Delphinapterus leucas) population is one of the smallest in the world, making it particularly vulnerable to challenges such as climate change and pathogens. In this study, serum samples from live captured (2001-2016) white whales from this region were investigated for influenza A virus (IAV) antibodies (Abs) (n = 27) and RNA (n = 25); morbillivirus (MV) Abs (n = 3) and RNA ...
    • Pestivirus Infections in Semi-Domesticated Eurasian Tundra Reindeer (Rangifer tarandus tarandus): A Retrospective Cross-Sectional Serological Study in Finnmark County, Norway. 

      Neves, Carlos Gonzalo das; Johansson Wensman, Jonas; Nymo, Ingebjørg Helena; Skjerve, Eystein; Alenius, Stefan; Tryland, Morten (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-26)
      Members of the Pestivirus genus (family <i>Flaviviridae</i>) cause severe and economically important diseases in livestock. Serological studies have revealed the presence of pestiviruses in different cervid species, including wild and semi-domesticated Eurasian tundra reindeer. In this retrospective study, serum samples collected between 2006 and 2008 from 3339 semi-domesticated Eurasian reindeer ...
    • Pharmacokinetics of a long-acting subcutaneous eprinomectin injection in semi-domesticated reindeer (Rangifer tarandus tarandus) - a pilot study 

      Davidson, Rebecca K.; Fæste, Christiane Kruse; Uhlig, Silvio; Tukun, Feng-Ling; Lian, Hans Edvin; Solvang, Hans Arne; Thorvaldsen, Renate; Folkow, Lars; Sanchez Romano, Javier; Kilvær, Marianne V.; Holmgren, Karin Elisabeth; Nymo, Ingebjørg Helena (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-17)
      Reindeer (Rangifer tarandus tarandus) are exposed to the pathogenic parasitic nematode Elaphostrongylus rangiferi during grazing. The severity of disease is dose-dependent. Prophylactic anthelmintic treatment is needed to improve animal health and reindeer herding sustainability. Herds are traditionally only gathered once during the summer, requiring a drug with a persistent effect. In this study ...
    • The quest for a true One Health perspective of brucellosis 

      Godfroid, Jacques; De Bolle, Xavier; Roop, R. Martin I.I.; O'Callaghan, David; Tsolis, Renée M.; Baldwin, Cynthia L.; Santos, Renato L.; McGiven, John A.; Olsen, Steven C.; Nymo, Ingebjørg Helena; Larsen, Anett Kristin; Al Dahouk, Sascha; Letesson, Jean-Jacques (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
    • A Screening for Virus Infections among Wild Eurasian Tundra Reindeer (Rangifer tarandus tarandus) in Iceland, 2017–2019 

      Tryland, Morten; Sanchez Romano, Javier; Nymo, Ingebjørg Helena; Mørk, Torill; Þórarinsdóttir, Rán; Breines, Eva Marie; Li, Hong; Cunha, Cristina Wetzel; Thórisson, Skarphéðinn G. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-23)
      A winter population of around 4000–5000 wild Eurasian tundra reindeer (<i>Rangifer t. tarandus</i>) in the eastern part of Iceland represents descendants from 35 semi-domesticated reindeer imported to Iceland from Finnmark county, Norway, in 1787. While previous studies have indicated that they host fewer parasite species as compared to reindeer in Fennoscandia, little information exists on their ...
    • A Screening for Virus Infections in Eight Herds of Semi-domesticated Eurasian Tundra Reindeer (Rangifer tarandus tarandus) in Norway, 2013–2018 

      Tryland, Morten; Sanchez Romano, Javier; Nymo, Ingebjørg Helena; Breines, Eva Marie; Murguzur, Francisco Javier Ancin; Kjenstad, Ole Christian; Li, Hong; Cunha, Cristina W. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-12)
      Background: Previous serological screenings have indicated that Eurasian semi-domesticated tundra reindeer (Rangifer tarandus tarandus) in Finnmark, Northern Norway, are exposed to alphaherpesvirus, gammaherpesvirus and pestivirus. Alphaherpesvirus (i.e., Cervid herpesvirus 2; CvHV2) has been identified as the transmissible component of infectious keratoconjunctivitis (IKC). Limited knowledge exists ...
    • Serological evidence of hepatitis e virus infection in semi-domesticated eurasian tundra reindeer (Rangifer tarandus tarandus) in norway 

      Rinaldo, Christine Hanssen; Nymo, Ingebjørg Helena; Sanchez Romano, Javier; Breines, Eva Marie; Murguzur, Francisco Javier Ancin; Tryland, Morten (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-25)
      Hepatitis E virus (HEV) is a common cause of viral hepatitis in humans. In developing countries, HEV-infections seem to be mainly associated with pigs, but other animal species may be involved in viral transmission. Recently, anti-HEV antibodies were detected in Norwegian wild reindeer. Here, we investigated anti-HEV seroprevalence in Norwegian semi-domesticated reindeer, animals in closer contact ...